Archive for the ‘Mouse’ Category

Circuit Neuroscience Recently, research into psychiatric disease has made great strides, but continued progress may require unpopular and ethically murky research. Joshua Gordon, the new director of the National Institutes of Mental Health writes in this month’s Nature Neuroscience: “At this unique and exciting time for psychiatry, novel therapies for individuals with mental illnesses seem just around […]

5-hydroxy-methyl CpGs (5-hmCs) were first discovered in 2009 and shown to be enriched in the brain, but remain a mysterious epigenetic mark, despite intriguing functional findings such as: environmental enrichment’s reduction of it, MeCP2’s preference for 5mc over 5hmc, and it’s possible role as an intermediate in demethylation. This new technique will aid their characterization […]

Despite having cared for laboratory mice for years, I’m wowed by the complexity of this task! The trainer’s site: describes the animals living conditions and training method. The trainer keeps the mice housed in groups of 3-4 females, in 3-dimensional cages such as a remodeled cupboard, or: a pyramid of different-sized tables, the several floors […]

The connectome  is a map of all neural connections in a brain, which I believe only currently exists for the flatworm C. Elegans. Seung’s group and collaborators are working using serial electron microscopy, and partially automated EM analysis and the crowdsourcing site eyewire  to reconstruct parts of the mouse retina, with the hope of steadily improving technologies […]

Detecting 5-hmCs 5-hydroxymethylcytosines (5-hmC) went undiscovered because they showed up like other 5-methoxycytosines through bisulfide sequencing. The neuroscientists behind a new study in Nature Neuroscience profiles 5-hmC across development using T4 bacteriophage B-glucosyltransferase to transfer an engineered glucose-azide moiety onto the the hydroxyl of 5-hmC. This moiety was then detected and used to map 5-hmCs […]

Viberg of the Eriksson lab in Sweden shows in a new paper in Toxicology (full text) that a single exposure to BPA on postnatal day 10 has dose-dependent effects. (Mice sexually mature around p45.) The paper is still in press, so details are sparse, but authors saw changes in spontaneous behavior when exposed to a […]