Aging | Neuroamer

Archive for the ‘Aging’ Category

Epigenetics and The Brain — 5-hydroxy-methocytosines

31Oct11

Detecting 5-hmCs 5-hydroxymethylcytosines (5-hmC) went undiscovered because they showed up like other 5-methoxycytosines through bisulfide sequencing. The neuroscientists behind a new study in Nature Neuroscience profiles 5-hmC across development using T4 bacteriophage B-glucosyltransferase to transfer an engineered glucose-azide moiety onto the the hydroxyl of 5-hmC. This moiety was then detected and used to map 5-hmCs […]

Filed under: Aging, Epigenetics, Genetics, Molecular, Mouse | Leave a Comment
Tags: 5-hmC, B-glucosyltransferase, DIPseq, MECP2, TET

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Current Neuroscience Book Recommendation:

In Search of Memory -Eric Kandel
Kandel’s book is a nobel prize winner's memoir that spans from his Jewish childhood in Nazi-occupied Vienna to his work on sea slugs that uncovered synaptic plasticity, the molecular foundation of learning and memory. When I graduated college, every neuroscience major was given a copy of this book.
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